The group of death! Apart from German Champions Bayern Munich, all the other three teams still have a chance to qualify for the round of sixteen.
Roma take on Manchester City and Bayern take on CSKA Moscow. The groups permutations and combinations of the teams going in is very complex.
Roma's fate is in their own hands as a win will be enough for them while a draw, could send either themselves or City through, depending on CSKA's result against Bayern.
City who have never won in their past four visits of Italy, that is even if they win today they could go out depending on the Bayern game.
Views from the players:
"City are obliged to win. They have all the pressure. Not Roma. City are in the same period that Chelsea used to be before they won it. It becomes complex until you win the trophy," Roma's Ivorian striker Gervinho said.
Where as City's midfielder James Milner believes that even without Aguero and Toure City can get the result they need.
"Sergio is a world class player, and has been outstanding all season so the injury has come at a bad time.
"He is going to be very difficult to replace and even without him and Yaya (Toure) we have a fantastic squad of players and, with the players, we have I am not too worried."
"We've had to win our last two games to qualify and I believe we can win in Rome after beating Bayern."
Prediction:
Roma 2-3 City